STAT3 and experimental autoimmune encephalomyelitis: In addition, SH479, a derivative of betulinic acid, ameliorated experimental autoimmune encephalomyelitis in a mouse model by modulating the Th17/Treg balance, on inhibiting the signal transducer and activator of transcription 3 (STAT3) and the nuclear factor kappa-light-chain-enhancer of activated B-cell (NF-κB) pathways and activating the STAT5 pathway [4].