RAGE signaling contributes to many physiological and pathophysiological processes and diseases such as innate immune responses, tissue repair, bone homeostasis, complications of diabetes, Alzheimer’s disease, as well as cancers (brain, breast, colon, colorectal, prostate, pancreatic oral squamous cell, ovarian cancer, and melanoma) [101,102,103,104,105,106,107,108,109]. The gene discussed is AGER; the disease is cancer.