Thirteen studies reported fibroblast reprogramming using modRNAs encoding pluripotent factors and generated disease iPSCs from patients with diseases such as cystic fibrosis [47], Huntington’s disease [56], DiGeorge syndrome [63], low-density lipoprotein receptor (LDLR) deficiency [64], and Down syndrome [70]. The gene discussed is LDLR; the disease is Down syndrome.