MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), frontotemporal lobar dementia (FTLD), chronic traumatic encephalopathy, and primary age related tauopathy are all neurodegenerative disorders known as tauopathies defined by the misfolding and aggregation of hyperphosphorylated tau proteins [5,6,7,8,9] while other proteins, such as α-synuclein, prions, huntingtin lead to Parkinson’s, prior diseases, and Huntington’s disease, respectively [10,11,12,13] to name few.