CASP12 and retinal degeneration: The relative levels of RIP3, cleaved RIP1 and MLKL proteins were also analyzed by western blot since necroptosis also contributes to retinal cell death during MCMV retinitis [42] and in several animal models of retinal degeneration [54,55,56,57] while a previous report showed that caspase-12 binds to RIP kinase via its kinase domain [37].