Moreover, reversing the dysregulated metabolism of glucose and fatty acid in colon cancer by dihydrotanshinone I (DHTS) has been shown to be linked to lower levels of SIRT3 gene expression within a metabolic reprogramming occurring through the PTEN/AKT/RHEB/MTOR/HIF1α signal pathway [13]. This evidence concerns the gene SIRT3 and malignant colon neoplasm.