In line with evidence showing that Parkin-mediated mitophagy is antagonized by the overexpression of pro-survival Bcl-2-family proteins [34], we found that δVB upregulated the Bax/Bcl-2 ratio and exasperated mitochondrial dysfunction by leading mitochondria membrane depolarization, thus supporting the role of δVB as a pro-apoptotic agent of colon cancer cells acting via mitophagy. This evidence concerns the gene PRKN and malignant colon neoplasm.