Consistently, miR-129-5p mimic prevented NF-kB signaling in autoimmune diseases by inhibiting TLR4 or TLR2-HMGB1 pathway [130,131] and attenuated neuroinflammation after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway [132]. This evidence concerns the gene HMGB1 and autoimmune disease.