CASP3 and silicosis: Furthermore, the silicosis animal or cell model should be established more cautiously due to the complex composition of silica; (3) Many related mechanisms, like the bidirectional effect of TNF-α in silica-induced apoptosis, or the regulatory function by caspase-3 on pyroptosis deserves further discussion; (4) Pyroptosis may be a potential mechanism during the development of silicosis, and it should also be regarded as an “outcome variable” to assess the severity of pathological changes in silicosis.