Furthermore, the silicosis animal or cell model should be established more cautiously due to the complex composition of silica; (3) Many related mechanisms, like the bidirectional effect of TNF-α in silica-induced apoptosis, or the regulatory function by caspase-3 on pyroptosis deserves further discussion; (4) Pyroptosis may be a potential mechanism during the development of silicosis, and it should also be regarded as an “outcome variable” to assess the severity of pathological changes in silicosis. Here, TNF is linked to silicosis.