LNCaP, an androgen-dependent prostate cancer cell line, expresses KRT18 but not KRT5 [30]; however, androgen-independent lines DU145 and PC3 both express basal cell keratins KRT5. The expression of KRT5 in the absence of KRT14 identifies the existence of an intermediate cell population in prostate carcinomas, and the number of KRT5-expressing cells increases significantly after androgen deprivation therapy [54]. Here, KRT18 is linked to Familial prostate cancer.