We herein demonstrate the enrichment of the “cytoskeleton remodeling–keratin filaments” pathway in cSCs from PCa specimens, identifying both normal stemness genes (PSCA, CD36, and SPINK1) and stem cell keratins (KRT13, 23, 80, 78, and 4) as well as distinctive keratins (KRT10, 19, 6C, and 16) in the cSC population. The gene discussed is SPINK1; the disease is posterior cortical atrophy.