NFKB1 and cancer: MMPs induced by pro- and inflammatory factors and regulated by NF-κB [32], as mentioned above, have an important role in sustaining all six major hallmarks of cancer [33] highlighted within the complexity of cancer biology: (1) sustaining proliferative signaling; (2) evasion of apoptosis; (3) angiogenesis and lymphangiogenesis; (4) invasion and metastasis; (5) reprogramming of energy metabolism; and (6) evasion of the immune response.