To investigate the elevated susceptibility of FLT3 wild-type SKM-1 compared to FLT3-mutated MOLM-13 cells to AC-4-130, cell viability was determined in AML cells grown in the presence of bone marrow stroma cells secreting granulocyte and macrophage colony-stimulating factors (G-CSF, GM-CSF, M-CSF), and other cytokines thereby inducing STAT signaling. The gene discussed is CSF2; the disease is acute myeloid leukemia.