TP53 and cancer: Like its mouse homologue, mortalin in the perinuclear area was found to co-localize with the tumor suppressor protein p53 in several cancer cell lines, thereby sequestering p53 and inhibiting the expression of several important p53 target genes, such as CDKN1A (which encodes p21, cyclin-dependent kinase inhibitor 1), MDM2 (an E3 ubiquitin-protein ligase), BAX (an apoptosis regulator), or FAS (tumor necrosis factor receptor superfamily member 6) [122,124,128,129].