HSPA9 and even-plus syndrome: Moreover, genetic mutations in genes encoding HSPs were shown as causative agents of several hereditary autosomal dominant or recessive disorders (e.g., hereditary spastic paraplegia SPG13, MitCHAP-60, EVEN-PLUS syndrome, and congenital sideroblastic anemia SIDBA4) suggesting that defects in mitochondrial chaperones exert a profound impact on overall mitochondrial biogenesis, integrity, and function.