Previous reports indicated that MAPK1 contributes to the elevated secretion of monocyte chemoattractant protein-1 (MCP-1) [18], and MAPK3 is associated with enhanced mRNA levels of inflammatory markers, such as CCL2, IL1β, and TNF-α in obesity [19]. Here, MAPK3 is linked to obesity due to melanocortin 4 receptor deficiency.