ENTPD1 and neoplasm: Through CD39 and CD73 blockade, likely limiting the conversion of ATP/AMP into adenosine, many mouse, human and in vitro studies showed inhibition of both tumor growth and metastasis formation, generally associated with an increase of NK and/or CD8 T cell immune-mediated antitumor responses [21,25,33,40,41,42,43,44].