PLAU and pachyonychia congenita: Their experiment revealed that cathepsin B, MMP-1 and MMP-2, arginase and urokinase plasminogen activators, detected through liquid biopsy, represent great biomarkers for the detection of PC, thus establishing an enzymatic signature for PC and also proving that nanoparticles can be of use in the early detection of this type of cancer [36,37,38,39].