CD274 and neoplasm: Xue et al. developed a functional nanoplatform based on generation 5 (G5) poly(amidoamine) (PAMAM) dendrimer-entrapped gold nanoparticles (G-DENPs) as a nonviral vector for delivering PD-L1 small interfering RNA (siPD-L1) for subsequent PD-L1 gene silencing-mediated tumor immunotherapy.