On the cellular level, the introduced microbiota induced the formation of intra-tumoral granulomas, the secretion of IL-2 by dendritic cells (DC) and the accumulation of central memory (TCM) CD4+ T cells in tumor beds, as well as mesenteric and tumor-draining lymph nodes after 48 h of the first injection of anti-PD-1 therapy [30]. The gene discussed is CD4; the disease is neoplasm.