SERPINA1 and alpha 1-antitrypsin deficiency: Newby et al. showed some, although not significant, long-term variation (baseline median 281.4 nM (interquartile range (IQR) 168.4–332.9 nM) and after 12–24 months median 215.2 nM (IQR 135.6–352.9 nM)) in 39 PiZZ AATD patients who were naïve for AAT iv treatment [11].