The overexpression of EphB4 in the presence of endothelial Ephrin-B2 has been shown to induce similar effects by leading to an increase in melanoma cell repulsion from the endothelial cells, translating into a reduced number of spinal metastatic loci and a prolongation of the time window until neurological deficits occur [10]. This evidence concerns the gene EFNB2 and melanoma.