This group also showed that in a hemophilia repeated joint bleed mouse model, that while a single bolus i.a. injection of IL-4 and IL-10 was not as effective in modifying cartilage degeneration or synovial inflammation in the knee joint after a single joint bleed [213], four consecutive i.a. IL-4-10 fusion protein injections ameliorated cartilage damage better than bolus injection of soluble recombinant murine IL-4 and IL-10 alone [211] and decreased pain in a canine groove in vivo model of knee PTOA [174,214]. The gene discussed is IL4; the disease is hemophilia.