SAMHD1 and tropical spastic paraparesis: In relation to SAMHD1, recent data obtained from 22 HAM/TSP patients and 61 AC, again demonstrated that the rs6029941 (A/G) polymorphism in host dNTPase SAMHD1 is associated with increased HTLV-1 PLV in HTLV-1-infected individuals, suggesting that the polymorphism could be a factor contributing to the development of the symptoms of the disease [61].