In agreement with the observation about the role of PRAK in myocardial ischemia, PRAK deletion exacerbated myocardial dysfunction and promoted myocardial remodeling under the condition of HFD, indicating the critical role of PRAK in preservation of cardiac performance and that PRAK might share a similar functional role in myocardial infarction and high-fat diet intervention. Here, MAPKAPK5 is linked to myocardial infarction.