GRIN2B and neurodegenerative disease: In contrast, 4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl) phenol (ifenprodil) and its derivatives are NR2B-selective negative allosteric modulators [12], which interact with the ATD of the NR2B subunit through hydrophobic interactions and hydrogen bonds, providing protection in some neurodegenerative diseases [18,19].