APC and cancer: From the proof-of-principle work on human cancer tissue cells, p31comet and APC/CCdc20 are currently suggested to be the two best candidates to try and target, wherein it has been shown by RNAi that removing p31comet or Cdc20 function in the presence of a mitotic poison will greatly increase the promotion of apoptosis and block or decrease ‘mitotic slippage’ [8,9,10,11,12,13,14,15].