Going forward, in order to create a novel potential mitotic poison combinatorial anti-cancer therapeutic molecule, the goal in the field is to identify a small molecule that (i) only causes an extended mitotic arrest in the presence of a mitotic poison to prevent cancer cell ‘mitotic slippage’; (ii) does not affect MCC function; and (iii) specifically inhibits APC/CCdc20 and not APCCdh1, where the question remains: how can budding yeast help? Here, MCC is linked to cancer.