Since in adulthood, adipose tissue expansion occurs through adipocyte hypertrophy, a process that is related to greater adipose tissue inflammation [55], it is plausible to suggest that the adipose tissue inflammation that occurs in obesity could also reduce ACE2 functionality in this tissue, and thus somehow protect the host from a SARS-CoV-2 infection [9]. This evidence concerns the gene ACE2 and obesity due to melanocortin 4 receptor deficiency.