Although the IGF-1 neuromotor function correction to SCA3 84Q mice (unpublished data) was not as dramatic as that of 84Q mice with GH treatment (Figure S1), the metabolic features of the IGF-1-treated group became closer to those of the control 15Q group than to those of the pathological 84Q group, indicating IGF-1 affects cellular metabolism in SCA3. Here, ATXN3 is linked to Spinocerebellar ataxia type 3.