PTGS2 and injury: Similarly, Zhang et al. recently showed that the natural compound pterostilbene protects lipopolysaccharide-induced acute lung injury in mice through Nrf2-mediated inhibition of Cyclooxygenase-2 (COX-2), nitric oxide synthase (iNOS), TNF-α, IL-6 and IL-1β thus attenuating inflammatory response and oxidative stress [52].