Moreover, PFK-1, which phosphorylates fructose-6-P to fructose-1,6 bisphosphate (FBP), is also activated under hypoxic conditions by HIF-1-induced PFK-2/F-2,6-BPase, and the downregulation of the latter in cancer cells has been reported to inhibit tumor growth [39,40]. Here, SETD2 is linked to cancer.