Additionally, it has been reported that the angiotensin-converting enzyme 2 (ACE2), a cellular receptor key for the infection process mediated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and which mediates viral entry into the target cells, is decreased upon HIF-1α accumulation, which could translate into lesser infection and viral replication [126,130]. The gene discussed is ACE2; the disease is infection.