We will discuss options such as targeting mTOR pathway in subependymal giant cells astrocytomas (SEGAs) of tuberous sclerosis and BRAF V600E mutation in rare glial (pleomorphic xanthoastrocytomas) or glioneuronal (gangliogliomas) tumours, which are a model of how specific molecular treatments can also favourably impact seizures and quality of life. Here, BRAF is linked to pleomorphic xanthoastrocytoma.