For better understanding of alcohol-induced acute inflammatory responses in chronically injured liver, we recently modeled alcohol-associated ACLI based on the chronic plus binge ethanol feeding model [8] in ATP binding cassette subfamily B member 4 knock out (Abcb4−/−) mice, which resulted in exacerbated hepatic steatosis, liver injury, and inflammation [2]. This evidence concerns the gene ABCB4 and fatty liver disease.