In addition to its effects in the gastric body, H. pylori colonization in the mouse intestinal tract has been shown to increase production of c-myc, interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF), but reduced interferon-gamma (IFN-γ), with subsequent development of colorectal cancer [34,35]. The gene discussed is TNF; the disease is colorectal cancer.