TLR7 and Thrombocytopenia: In addition, TLR3 and TLR4 could be of particular importance in platelet responses during sepsis, because a deficiency in either of these receptors is associated with more severe thrombocytopenia during polymicrobial sepsis induced by a cecal ligation and puncture procedure, while TLR2- and TLR7-deficient mice displayed a less severe coagulopathy, suggesting a different pattern of TLR involvement in murine polymicrobial sepsis [203].