APOE and atherosclerosis: Moreover, ApoE-deficient mice lacking either MyD88 or TLR4 exhibited reduced aortic atherosclerosis, lower levels of proinflammatory IL-12 and CCL2, as well as lower macrophage infiltration in aortic sinus plaques, suggesting the role of innate immunity and danger signal receptors in the pathophysiology of atherosclerosis [230].