Interestingly, in contrast to the anti-fibrogenic role of Smad2 in UUO mouse kidney [72], conditional deletion of Smad2 from fibroblasts driven by the Fibroblast-specific Protein 1 (Fsp1) promoter reduces renal fibrosis in STZ-induced DN [78]. This evidence concerns the gene SMAD2 and liver dysplastic nodule.