Although there is no available genetic data for the role of TGFBR1 in kidney disease including DN, inhibition of TGFBR1 by the specific pharmaceutical inhibitors IN-1130 and SB-525334 can inhibit fibrosis in the rat models of UUO and puromycin aminonucleoside (PAN)-induced nephritis, respectively [67,68]. Here, TGFBR1 is linked to liver dysplastic nodule.