In PMA tumor tissue (Figure 5B), significant downregulation of HMG-CoA reductase (Hmgcr) and phosphomevalonate kinase (Pmvk) was detected compared to increased expression levels of mevalonate 5-disphosphate decarboxylase (Mvd), Farnesyl diphosphate synthase (Fdps), 3-hydroxy-3-methylglutaryl-CoA synthase (Hmgcs), isopentenyl diphosphate isomerase (Idi) and squalene synthase (Sqs), an mRNA encoding for ER enzyme. The gene discussed is HMGCR; the disease is neoplasm.