MTOR and Cognitive impairment: In particular, Berthoux and colleagues [99] have shown that co-administration during adolescence of THC and the 5HT6 receptor antagonist SB258585, was able to prevent long-lasting cognitive impairments and aberrations in cortical networks, such as sustained activation of mTOR, excitatory/inhibitory transmission imbalances as well as changes in the intrinsic properties of cortical pyramidal neurons and LTD (Table 1).