The expression of interferon-stimulated genes (ISG) (CCL2, IFI6, ISG15, PMAIP1, SAT1 and p21/CDKN1A) by MSC usually makes them resistant to viral infections, such as dengue virus, Ebola virus, influenza A virus and West Nile virus, inter alia. Here, CDKN1A is linked to viral infectious disease.