However, recent findings suggest that mGluR5 might exert region- and cell-type-specific effects on anxiety [37,40,41,42] and thus, we sought to explore whether mGluR5 located at D1 neurons could mediate these behavioral expressions at baseline and explain the passive stress response of mGluR5D1 cKO mice in the FST. The gene discussed is GRM5; the disease is Anxiety.