To examine the potential link between retinal degeneration and the innate immune response, we first analyzed expression of Tlr2 and TLR-adaptor genes in two genetically unrelated RP mouse models, the rd10 (Pde6brd10/rd10) mouse and the P23H/+ (RhoP23H/+) mouse. Here, TLR2 is linked to retinitis pigmentosa 1.