NOS3 and Hypertension: Table 3 shows only few ADMA-lowering agents have been examined in the developmental programming models to prevent hypertension, including NAC [103], resveratrol [104], melatonin [115], and aliskiren [116]. Moreover, in mother rats that received melinjo (Gnetum gnemon) seed extract during lactation the development of hypertension programmed by excessive fructose intake in their female offspring could be prevented by enhancing eNOS expression [117].