Similar to hepatic ISG expression, which is known to be stimulated in HCV-infections in nontumorous conditions, hepatic ISG expression was found to be activated in malignant tissue—specifically in patients with HCV infections as a risk factor—as well (p = 0.0027, p = 0.0001, and p = 0.0148 for Mx1, IFI44, and IFIT1, respectively, Kruskal–Wallis test, Supplementary Materials Figure S1). The gene discussed is MX1; the disease is infection.