Another mechanism of action of quercetin is associated with modulation of the methylation status of promoter regions of genes involved in tumor suppression through the cell cycle control (P16INK4a or CDKN2A and RASSF1a for Ras associated domain family protein 1 isoform A) and estrogenic transduction (estrogen receptor beta Er-beta or ESR2). Here, CDKN2A is linked to neoplasm.