Thus, RSV- piceatannol-induced PD-L1 expression may serve as a Search, Enhance and Engage (“SEE”) signal to sensitize low PD-L1-expressing “non-responsive” tumors, augmenting their detection by PD-1/PD-L1 immune checkpoint blockade (PD-1 and PD-L1 inhibitors) and finally leads to the elimination of cancer cells by antitumor immunity. This evidence concerns the gene CD274 and cancer.