SIRT1 and transitional cell carcinoma: Interestingly, the subsequent study showed that RSV-exposed transitional carcinoma cells were characterized by reduced cell growth, apoptosis and cell cycle arrest, which were accompanied by inhibition of the STAT3 (signal transducer and activator of transcription) signaling pathway, Sirt1 (Sirtuin 1) and p53 nuclear translocations [80].