In vivo study confirmed that the curcumin administration might lead to induction of tumor antigen-specific T cells in the restoration of dendritic cells pathway directly by inhibiting STAT3 (signal transducer and activator of transcription 3) and indirectly via reduced IL-6 (interleukin 6) production from STAT3 activated cancer cells in the murine tumor models. The gene discussed is STAT3; the disease is neoplasm.