While various studies have investigated TDP-43 proteinopathy across CNS inflammatory disorders outside of neurodegeneration (i.e., stroke and TBI), further research is warranted to investigate the precise mechanisms underlying the highlighted associations to fully explore the paradigm between TDP-43 proteinopathy and acute or chronic CNS insults such as cerebral ischemia and brain trauma. The gene discussed is TARDBP; the disease is proteostasis deficiencies.