In the largest cohort of unrelated patients with FTD-TDP to date, Pottier and colleagues performed a comprehensive genome wide association study (GWAS) and identified significant genomic loci within the human leukocyte antigen (HLA) locus (HLA-DQAZ, cell-surface proteins responsible for the regulation of the immune system) in addition to a rare loss of function variants in genes involved in the TBK1-immunity pathway [46]. Here, TBK1 is linked to frontotemporal dementia.