There is increasing evidence to suggest a significant link between brain trauma and TDP-43, with multiple clinical studies and preclinical models of TBI, both single and repetitive, consistently exhibiting TDP-43 proteinopathy including its cleavage, phosphorylation, mislocalisation, and cytoplasmic aggregation [166,167,168,169,170,171,172]. This evidence concerns the gene TARDBP and brain injury.