It is important to appreciate that much can be learned from researching TDP-43 proteinopathy in the context of diseases outside of the typical focus of neurodegenerative diseases, material that could be used to further understand TDP-43’s role within the CNS and inform therapeutic targets and pathways that could be manipulated in the context of ALS and FTD. Here, TARDBP is linked to amyotrophic lateral sclerosis.