In a histopathological study performed on human brain tissue biopsies from a panel of anoxic, ischemic, and neoplastic lesions, Lee and colleagues reported an absence of TDP-43 inclusions in ischemic stroke in addition to anoxia and neoplasms, indicating that ischemia does not result in aberrant mislocalisation or accumulation of TDP-43 [159]. The gene discussed is TARDBP; the disease is ischemic stroke.