TARDBP and neurodegenerative disease: In the context of neurodegenerative disease TDP-43 has been shown to directly interact with p65 colocalising in the nucleus of neurons in CNS samples from ALS patients [116], patients with mild cognitive impairment (MCI) and episodic memory deficits [120], and in transgenic mice that overexpress human wild type and mutant TDP-43 [116].