In order to accurately determine the frequency of carriage of thrombophilia polymorphisms, such as FVL, FII20210A, 677MTHFR(Т), PLA1/A2 and 4G/4G PAI-1, in healthy age-matched non-pregnant subjects, we utilized a group of 82 women and compared the data with those obtained for the EPL1 group of patients (since the CNP, CP and EPL2 groups were very scarce for statistical evaluation of mutation carriage). This evidence concerns the gene EPC1 and Rare hereditary thrombophilia.