In recent years, a number of synthetic PPAR ligands have been generated, with fibrates (e.g., fenofibrate, clofibrate, and gemfibrozil) and thiazolidinediones (TZDs:, e.g., rosiglitazone and pioglitazone) used to treat dyslipidemia and diabetes, respectively [125]. Here, PPARA is linked to diabetes mellitus.