Subsequently, in numerous investigations performed in vitro and in animal models, it has been established that RSV mainly (i) regulates high blood pressure and ameliorates vascular biology [121]; (ii) counteracts NAFLD progression [122]; (iii) improves insulin sensitivity [123]; (iv) promotes adipose tissue remodeling [124]; and (v) modifies gut microbiota composition [125], acting on the same mechanism activating by CR. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.