However, this study has identified that the Taekwondo training with moderate intensity of RPE 10-13 among aged women with depression brings out the interaction effects of BDNF (p < 0.01) and β-amyloid(p < 0.05) despite no significant changes in irisin, which is a meaningful result that has comparatively analyzed the dependent variables of dementia. Here, FNDC5 is linked to major depressive disorder.