Of note, Arg1 mRNA expression in the spleen was lower in infected and CB-1158-treated mice as compared to infected and untreated littermates (Figure 4d), whereas Arg1 expression in the liver was neither induced by infection nor reduced by CB-1158, largely confirming the results obtained with ARG1-deficient Tie2Cre+/−ARG1fl/fl mice (Figure 3d). This evidence concerns the gene ARG1 and infection.