In contrast, in L. major infections of BALB/c mice, the deletion of ARG1 was associated with a significant reduction in the tissue pathogen load from day 20 of infection onwards [10], while at earlier time points of infection the parasite burden was comparable in Tie2Cre+/−ARG1fl/fl and Tie2Cre−/−ARG1fl/fl BALB/c mice. Here, ARG1 is linked to infection.