The studies can be categorized in (i) descriptive studies focusing basal AMPK activity in obesity/insulin resistance [183,184,185], (ii) interventional studies using AMPK mimetics under in vivo or ex vivo conditions [97,182,184,186,187,188], and (iii) exercise studies (e.g., [187,189,190,191,192]). Here, PRKAA1 is linked to obesity due to melanocortin 4 receptor deficiency.