HMOX1 and ischemic stroke: As a regulator, Nrf2 also mediates the expression of many genes encoding cytoprotective, antioxidant, and anti-inflammatory proteins, such as heme oxygenase 1 (HO-1), peroxidase,glutamate cysteine ligase, and glutathione peroxidase, and can directly participate in the protection of brain cells from the damage associated with ischemic stroke [134].