In this study, we tried to assess the potential immunogenicity of murine glial restricted progenitors (GRPs) transplanted directly into cisterna magna of ALS B6SJL-Tg(SOD1*G93A)1Gur/J male mouse model and involvement of neuroimmune response to GRPs administration in semiallogeneic (DBA1/J), allogeneic (C57BL/6), and immunodeficient (SCID) male mouse model. Here, SOD1 is linked to amyotrophic lateral sclerosis.